{"id":3127,"date":"2025-10-27T13:22:47","date_gmt":"2025-10-27T13:22:47","guid":{"rendered":"https:\/\/www.lmaclinic.com\/lma\/?p=3127"},"modified":"2025-10-27T13:22:48","modified_gmt":"2025-10-27T13:22:48","slug":"what-are-the-side-effects-of-julaine-collagen-treatment","status":"publish","type":"post","link":"https:\/\/www.lmaclinic.com\/lma\/blog\/what-are-the-side-effects-of-julaine-collagen-treatment","title":{"rendered":"What Are the Side Effects of Jul\u00e4ine Collagen Treatment?"},"content":{"rendered":"\n
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If you\u2019ve been exploring the world of advanced skin rejuvenation, you\u2019ve probably come across Jul\u00e4ine one of the latest collagen-stimulating injectables designed to improve firmness, elasticity, and hydration from within.<\/p>\n\n\n\n

Unlike traditional fillers that simply add volume, Jul\u00e4ine works by activating your skin\u2019s natural regenerative processes, helping it rebuild collagen and elastin over time. The result is smoother, more resilient skin with a healthy, youthful glow.<\/p>\n\n\n\n

But, like any injectable treatment, you may wonder: \u201cAre there any side effects?\u201d<\/p>\n\n\n\n

The short answer is that Jul\u00e4ine is considered safe when performed by trained professionals. Still, as with all medical aesthetic procedures, there are temporary effects and aftercare steps you should be aware of.<\/p>\n\n\n\n

In this article, I\u2019ll explain what happens after treatment, what side effects are normal, when to seek advice, and how to ensure the best possible outcome.<\/p>\n\n\n\n

Understanding How Jul\u00e4ine Works<\/strong><\/p>\n\n\n\n

Before diving into side effects, it helps to understand what Jul\u00e4ine actually does beneath the skin.<\/p>\n\n\n\n

Jul\u00e4ine is an advanced biostimulatory collagen treatment, meaning it uses carefully formulated active ingredients to stimulate your body\u2019s own production of collagen and elastin the two key proteins responsible for keeping skin firm and smooth.<\/p>\n\n\n\n

Over time, these proteins naturally decline, leading to:<\/p>\n\n\n\n

– Sagging or loss of firmness<\/p>\n\n\n\n

– Fine lines and wrinkles<\/p>\n\n\n\n

– Dullness or dehydration<\/p>\n\n\n\n

– Reduced elasticity<\/p>\n\n\n\n

Jul\u00e4ine contains a combination of biocompatible substances designed to encourage fibroblast activity the cells that generate new collagen fibres. When injected into precise areas, it gradually improves the structure and texture of the skin from within.<\/p>\n\n\n\n

You won\u2019t see an instant volumising effect as you would with a filler. Instead, results appear progressively over several weeks as your skin regenerates naturally.<\/p>\n\n\n\n

Is Jul\u00e4ine Safe?<\/strong><\/p>\n\n\n\n

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Yes Jul\u00e4ine is considered very safe when administered by a qualified medical practitioner using the correct technique.<\/p>\n\n\n\n

Its formulation is biocompatible and biodegradable, meaning it integrates smoothly into the skin and is eventually broken down by your body.<\/p>\n\n\n\n

Clinical studies and early adopters in the aesthetics field have reported high satisfaction rates with minimal downtime and few side effects.<\/p>\n\n\n\n

However, as with any injectable, the treatment involves puncturing the skin which means mild, short-lived reactions are possible.<\/p>\n\n\n\n

Common and Expected Side Effects<\/strong><\/p>\n\n\n\n

Most side effects associated with Jul\u00e4ine are mild, temporary, and part of your body\u2019s natural healing process.<\/p>\n\n\n\n

Here\u2019s what you may experience and why it happens.<\/p>\n\n\n\n

1. Redness at Injection Sites<\/strong><\/p>\n\n\n\n

Mild redness is extremely common and occurs due to minor inflammation caused by the needle entering the skin.<\/p>\n\n\n\n

It usually appears immediately after treatment and fades within a few hours to 24 hours. You can safely return to work or social activities shortly after your session.<\/p>\n\n\n\n

How to manage:<\/strong><\/p>\n\n\n\n

– Avoid touching or rubbing the area.<\/p>\n\n\n\n

– Use a cool compress to reduce warmth.<\/p>\n\n\n\n

– Skip makeup for 12\u201324 hours if possible.<\/p>\n\n\n\n

2. Mild Swelling<\/strong><\/p>\n\n\n\n

A small amount of swelling is normal as the skin reacts to both the injection and the active ingredients.<\/p>\n\n\n\n

This may make the treated area appear slightly puffy or tender for a day or two.<\/p>\n\n\n\n

How to manage:<\/strong><\/p>\n\n\n\n

– Keep your head elevated while resting.<\/p>\n\n\n\n

– Avoid alcohol, salty foods, and strenuous activity for 24 hours.<\/p>\n\n\n\n

– Use a cold compress intermittently.<\/p>\n\n\n\n

3. Bruising<\/strong><\/p>\n\n\n\n

Even with expert technique, tiny blood vessels beneath the skin can sometimes break, resulting in small bruises.<\/p>\n\n\n\n

These are harmless and typically fade within 5\u20137 days.<\/p>\n\n\n\n

How to manage:<\/strong><\/p>\n\n\n\n

– Apply arnica gel to help bruises heal faster.<\/p>\n\n\n\n

– Avoid aspirin or anti-inflammatory medications before treatment unless prescribed.<\/p>\n\n\n\n

– Use gentle concealer after 24 hours if needed.<\/p>\n\n\n\n

4. Tenderness or Mild Soreness<\/strong><\/p>\n\n\n\n

Because Jul\u00e4ine is injected into the mid-to-deep layers of the skin, mild tenderness is expected.<\/p>\n\n\n\n

You may feel slight discomfort when touching the area, similar to post-exercise soreness. This sensation usually resolves within a couple of days.<\/p>\n\n\n\n

How to manage:<\/strong><\/p>\n\n\n\n

– Avoid facial massages or pressure on the area for at least 72 hours.<\/p>\n\n\n\n

– Use paracetamol if needed (avoid ibuprofen as it can worsen bruising).<\/p>\n\n\n\n

5. Small Lumps or Bumps (Injection Nodules)<\/strong><\/p>\n\n\n\n

Immediately after treatment, you may feel small raised bumps under the skin. These are simply the product deposits before they integrate fully.<\/p>\n\n\n\n

They usually smooth out on their own within a few days as the product disperses naturally.<\/p>\n\n\n\n

How to manage:<\/strong><\/p>\n\n\n\n

– Do not press, squeeze, or massage unless instructed by your practitioner.<\/p>\n\n\n\n

– Keep the area clean and avoid applying excessive creams or oils.<\/p>\n\n\n\n

6. Mild Itching or Warmth<\/strong><\/p>\n\n\n\n

A mild warm or tingling sensation can occur as part of the skin\u2019s inflammatory healing response.<\/p>\n\n\n\n

This is usually temporary and may indicate that collagen stimulation is beginning to take place.<\/p>\n\n\n\n

How to manage:<\/strong><\/p>\n\n\n\n

– Avoid scratching or using fragranced products.<\/p>\n\n\n\n

– Use a gentle, soothing moisturiser if needed.<\/p>\n\n\n\n

Less Common Side Effects<\/strong><\/p>\n\n\n\n

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While rare, there are a few less frequent side effects you should be aware of.<\/p>\n\n\n\n

These are typically related to individual skin sensitivities or improper aftercare.<\/p>\n\n\n\n

1. Prolonged Swelling or Firmness<\/strong><\/p>\n\n\n\n

Occasionally, swelling may last more than 72 hours. This can happen if your body takes longer to process the injectable or if the treated area experiences minor irritation.<\/p>\n\n\n\n

If swelling persists beyond a few days, consult your practitioner for assessment.<\/p>\n\n\n\n

2. Localised Inflammation or Redness<\/strong><\/p>\n\n\n\n

If redness or heat persists for more than three days, it could indicate irritation or a mild infection.<\/p>\n\n\n\n

Keep the area clean, avoid makeup, and contact your clinician if symptoms worsen.<\/p>\n\n\n\n

3. Allergic Reaction (Extremely Rare)<\/strong><\/p>\n\n\n\n

Because Jul\u00e4ine is made from biocompatible materials, allergic reactions are highly uncommon. However, if you have a history of allergies or sensitivities, discuss this during your consultation.<\/p>\n\n\n\n

Watch for signs such as:<\/p>\n\n\n\n

– Persistent swelling<\/p>\n\n\n\n

– Severe itching<\/p>\n\n\n\n

– Rash or hives<\/p>\n\n\n\n

If these occur, seek medical attention immediately.<\/p>\n\n\n\n

4. Temporary Unevenness<\/strong><\/p>\n\n\n\n

In some cases, one area may appear slightly more lifted or plumper than another during the early healing phase.<\/p>\n\n\n\n

This balances out as collagen stimulation evens the skin\u2019s texture and tone over several weeks.<\/p>\n\n\n\n

What You Should Expect After Treatment<\/strong><\/p>\n\n\n\n

Jul\u00e4ine has a relatively short recovery period compared to other collagen-stimulating injectables, so most people can get back to their normal activities almost immediately.<\/p>\n\n\n\n

In the first 24 hours, you might notice some redness, swelling, or mild tenderness at the injection sites. During this time, it\u2019s best to avoid makeup, strenuous exercise, and alcohol to allow your skin to settle. By day two or three, slight bruising or small bumps may appear. Continuing gentle skincare and staying well-hydrated can help your skin recover smoothly.<\/p>\n\n\n\n

Around day four to seven, you should start to feel your skin becoming smoother as initial inflammation fades. If you want, you can resume wearing light makeup during this period. By the second to fourth week, the collagen-stimulating effects of Jul\u00e4ine start to kick in more noticeably, so make sure to protect your skin with SPF and keep using a barrier-repair moisturiser to support healthy skin function.<\/p>\n\n\n\n

Between the second and third month, most people see visible results: firmer, more radiant, and refreshed-looking skin. Maintaining a healthy diet, staying hydrated, and following your post-treatment skincare routine will help you get the most out of your treatment.<\/p>\n\n\n\n

Tips to Minimise Side Effects and Support Healing<\/strong><\/p>\n\n\n\n

1. Choose a Qualified Practitioner<\/strong>
Always get your Jul\u00e4ine treatment from a licensed medical professional. Proper technique reduces the risk of bruising, swelling, or uneven results.<\/p>\n\n\n\n

2. Avoid Blood-Thinning Substances<\/strong>
For at least 48 hours before your appointment, try to avoid alcohol, fish oil, or anti-inflammatory medication (unless prescribed).<\/p>\n\n\n\n

3. Don\u2019t Touch or Massage the Area<\/strong>
Let the product settle naturally. Massaging prematurely may cause lumps or migration.<\/p>\n\n\n\n

4. Keep Skin Clean and Calm<\/strong>
Skip exfoliation, saunas, and steam rooms for 48 hours. Use mild, fragrance-free cleansers and moisturisers.<\/p>\n\n\n\n

5. Protect from Sun Exposure<\/strong>
UV light can trigger inflammation and pigment changes after injectables. Use broad-spectrum SPF 30+ daily.<\/p>\n\n\n\n

6. Stay Hydrated<\/strong>
Collagen synthesis requires adequate water intake. Aim for 6\u20138 glasses of water per day.<\/p>\n\n\n\n

7. Eat Collagen-Boosting Foods<\/strong>
Add vitamin C-rich fruits, leafy greens, and omega-3 fatty acids to support healing and skin regeneration.<\/p>\n\n\n\n

How Long Do Side Effects Last?<\/strong><\/p>\n\n\n\n

Most side effects from Jul\u00e4ine resolve within 2\u20135 days.<\/p>\n\n\n\n

Bruising may take up to a week to fade completely, depending on your skin type and circulation.<\/p>\n\n\n\n

If small nodules persist beyond 10\u201314 days, your practitioner may recommend a light massage or check-up to ensure full integration.<\/p>\n\n\n\n

When to Contact Your Practitioner<\/strong><\/p>\n\n\n\n

While serious complications are rare, it\u2019s important to monitor your skin carefully in the first few days after treatment.<\/p>\n\n\n\n

Call your clinic immediately if you experience:<\/p>\n\n\n\n

– Severe or increasing pain<\/p>\n\n\n\n

– Spreading redness or swelling<\/p>\n\n\n\n

– Signs of infection (heat, discharge, fever)<\/p>\n\n\n\n

– Hard lumps that do not soften over time<\/p>\n\n\n\n

Your clinician can assess whether additional treatment or medication is needed.<\/p>\n\n\n\n

Comparing Jul\u00e4ine to Other Collagen Treatments<\/strong><\/p>\n\n\n\n

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You might hear Jul\u00e4ine compared to other collagen-stimulating treatments like Sculptra or Radiesse. While all of these aim to boost your skin\u2019s collagen, Jul\u00e4ine is generally gentler and integrates more naturally into the skin, which often means fewer side effects and a smoother overall result.<\/p>\n\n\n\n

Jul\u00e4ine works through collagen biostimulation, helping your skin rebuild its own structure over time. In comparison, Sculptra uses poly-L-lactic acid, while Radiesse relies on calcium hydroxyapatite to achieve similar effects. One of the benefits of Jul\u00e4ine is the minimal downtime most people experience only one to two days of mild redness or swelling, whereas Sculptra or Radiesse can require a few more days to settle, sometimes accompanied by lumps, firmness, or bruising.<\/p>\n\n\n\n

When it comes to seeing results, Jul\u00e4ine typically starts to show improvements in two to three months, similar to Radiesse, though Sculptra can take slightly longer. The effects of Jul\u00e4ine can last up to 18 months, offering long-lasting rejuvenation while maintaining a natural look. Its smooth texture and even dispersion make it a great option if you\u2019re looking for subtle but noticeable improvement without the extended recovery time that some other treatments may require.<\/p>\n\n\n\n

Who Should Avoid Jul\u00e4ine Treatment?<\/strong><\/p>\n\n\n\n

Jul\u00e4ine may not be suitable for everyone. Avoid treatment if you:<\/p>\n\n\n\n

– Are pregnant or breastfeeding<\/p>\n\n\n\n

– Have active skin infections or cold sores in the area<\/p>\n\n\n\n

– Are allergic to any component of the formula<\/p>\n\n\n\n

– Have autoimmune disorders affecting healing<\/p>\n\n\n\n

– Are on blood-thinning medication (consult your doctor first)<\/p>\n\n\n\n

A professional consultation will help determine whether Jul\u00e4ine is appropriate for your skin type and medical history.<\/p>\n\n\n\n

How to Ensure the Best Results<\/strong><\/p>\n\n\n\n

Achieving glowing, rejuvenated skin isn\u2019t just about the treatment it\u2019s also about how you care for your skin afterwards.<\/p>\n\n\n\n

1. Follow Aftercare Instructions Diligently<\/strong><\/p>\n\n\n\n

Your practitioner will provide personalised post-treatment guidance. Following it carefully prevents complications and optimises your outcome.<\/p>\n\n\n\n

2. Maintain a Consistent Skincare Routine<\/strong><\/p>\n\n\n\n

Use gentle cleansers, hydrating serums, and sunscreen daily. Avoid harsh exfoliants or retinoids for at least one week post-treatment.<\/p>\n\n\n\n

3. Book Follow-Up Appointments<\/strong><\/p>\n\n\n\n

Depending on your treatment plan, you may need multiple sessions to achieve full results. Follow-up visits allow your practitioner to monitor progress and fine-tune results.<\/p>\n\n\n\n

4. Prioritise Skin Health Long-Term<\/strong><\/p>\n\n\n\n

Support your collagen levels naturally by staying hydrated, eating antioxidant-rich foods, and avoiding smoking or excessive sun exposure.<\/p>\n\n\n\n

Frequently Asked Questions About Jul\u00e4ine Collagen Treatment<\/strong>:<\/p>\n\n\n\n

1. How long does it take to see results after Jul\u00e4ine treatment?<\/strong>
You can expect to notice gradual improvements in your skin\u2019s firmness and texture over the course of two to three months. Unlike traditional fillers, Jul\u00e4ine works by stimulating your body\u2019s own collagen production, so the results build progressively and continue to improve over time. Most patients see the full effect within three months, with results lasting up to 18 months depending on your skin type and lifestyle.<\/p>\n\n\n\n

2. Will Jul\u00e4ine make my skin look immediately plump?<\/strong>
Jul\u00e4ine is different from volumising fillers, so you won\u2019t see instant puffiness or dramatic plumping. The treatment focuses on enhancing your skin\u2019s natural structure and resilience, which gradually smooths fine lines, improves elasticity, and gives your skin a healthy, refreshed glow. Immediate changes are usually subtle, with more noticeable results appearing over several weeks as collagen production ramps up.<\/p>\n\n\n\n

3. What are the most common side effects of Jul\u00e4ine?<\/strong>
After treatment, you might experience mild redness, swelling, or tenderness at the injection sites. Small bruises or temporary nodules under the skin are also possible, and they generally resolve within a few days. Some people notice a slight warm or tingling sensation as part of the natural healing response. These effects are temporary and indicate that your skin is responding to the collagen-stimulating treatment.<\/p>\n\n\n\n

4. Is Jul\u00e4ine suitable for all skin types?<\/strong>
Jul\u00e4ine is generally safe for most skin types, but it may not be suitable if you have active skin infections, autoimmune conditions affecting healing, or known allergies to any component of the formula. It\u2019s also not recommended during pregnancy or breastfeeding. A professional consultation can help determine whether the treatment is appropriate for your individual skin and medical history.<\/p>\n\n\n\n

5. How long is the recovery period after Jul\u00e4ine injections?<\/strong>
Most people can return to their normal activities immediately after treatment, as the recovery is minimal. Redness and mild swelling typically last one to two days, while minor bruising or small bumps may persist for up to a week. Following aftercare guidance from your practitioner will help your skin settle more comfortably and support optimal results.<\/p>\n\n\n\n

6. Can I combine Jul\u00e4ine with other aesthetic treatments?<\/strong>
You can combine Jul\u00e4ine with other non-invasive treatments like Botox, light chemical peels, or laser therapy, but it\u2019s best to space out treatments according to your practitioner\u2019s advice. Combining treatments can enhance overall results, but timing is crucial to avoid overstressing your skin and to ensure each procedure works effectively.<\/p>\n\n\n\n

7. How can I minimise side effects after my Jul\u00e4ine session?<\/strong>
To reduce side effects, it\u2019s important to follow your practitioner\u2019s aftercare instructions closely. Avoid touching or massaging the treated areas, skip strenuous exercise, and stay out of saunas or steam rooms for the first 48 hours. Protecting your skin from sun exposure, staying hydrated, and eating a nutrient-rich diet will also support healing and collagen formation.<\/p>\n\n\n\n

8. Are there any long-term risks with Jul\u00e4ine?<\/strong>
When performed by a qualified medical professional, Jul\u00e4ine is considered very safe and biocompatible, with minimal long-term risks. Serious complications are extremely rare. Temporary nodules or unevenness may occur, but these usually resolve naturally as the product integrates into your skin and collagen production continues.<\/p>\n\n\n\n

9. How often should I have Jul\u00e4ine treatments to maintain results?<\/strong>
Maintenance depends on your skin\u2019s needs and how your body responds to the treatment. Many patients require a follow-up session after a few months to achieve the best results, and then periodic treatments every 12 to 18 months can help sustain the skin\u2019s firmness and hydration. Your practitioner will tailor the schedule to your individual goals and skin condition.<\/p>\n\n\n\n

10. Will Jul\u00e4ine help with deep wrinkles or sagging skin?<\/strong>
Jul\u00e4ine is most effective for improving skin texture, firmness, and mild to moderate signs of ageing. It may not provide dramatic correction for very deep wrinkles or significant sagging, which could require additional treatments or more targeted interventions. A consultation with your dermatologist will help determine if Jul\u00e4ine alone can meet your goals or if a combination approach is recommended.<\/p>\n\n\n\n

Final Thoughts: Maximising Your Jul\u00e4ine Results<\/strong><\/p>\n\n\n\n

Jul\u00e4ine offers an advanced yet natural way to enhance your skin\u2019s firmness, hydration, and elasticity without overfilling or altering your natural features. Instead of masking signs of ageing, it works with your body\u2019s own regenerative processes to restore youthful structure and radiance from within.<\/p>\n\n\n\n

To make the most of your results, consistency is key. Follow your practitioner\u2019s aftercare instructions carefully, protect your skin from UV damage with daily SPF, stay hydrated, and maintain a healthy lifestyle. Combining good skincare habits with your Jul\u00e4ine treatment ensures longer-lasting benefits and smoother, more resilient skin over time.<\/p>\n\n\n\n

If you\u2019re considering a Jul\u00e4ine treatment<\/a>, you can contact us at the London Medical & Aesthetic Clinic to discuss your personalised plan and discover how this advanced collagen stimulator can help you achieve natural, long-lasting rejuvenation.<\/p>\n\n\n\n

References:<\/strong><\/p>\n\n\n\n

1. Salvatore, L., Natali, M. L., Brunetti, C., Sannino, A. & Gallo, N. (2023) \u2018An update on the clinical efficacy and safety of collagen injectables for aesthetic and regenerative medicine applications\u2019, Polymers, 15(4), p. 1020. Available at: https:\/\/www.mdpi.com\/2073-4360\/15\/4\/1020<\/a><\/p>\n\n\n\n

2. Silva, M. L., Menezes, A., Guarnieri, C., Souza, M. & Pereira, R. F. (2023) \u2018Collagen stimulators in body applications: a review focused on poly-L-lactic acid\u2019, Journal of Dermatological & Cosmetic Surgery, 18(9), pp. 929\u2013935. Available at: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9233565\/<\/a><\/p>\n\n\n\n

3. Bravo, B. S. F., Cavalcante, T., Zafra, M. C. & Nobre, C. (2024) \u2018Exploring the safety and satisfaction of patients injected with a PLLA-based collagen biostimulator\u2019, Journal of Cosmetic Dermatology, [online ahead of print]. Available at: https:\/\/pubmed.ncbi.nlm.nih.gov\/39663956\/<\/a><\/p>\n\n\n\n

4. Christen, M.-O. (2022). Clinical Perspectives on the Safety Profile of Poly\u2010L\u2010Lactic Acid (PLLA) for Facial Rejuvenation: A Systematic Review. Journal of Clinical Aesthetic Dermatology, Available at: https:\/\/www.researchgate.net\/publication\/395351056_Clinical_Perspectives_on_the_Safety_Profile_of_Poly-L-Lactic_Acid_Julaine_Results_From_a_National_Survey<\/a><\/p>\n\n\n\n

5. Kubik, P., et al., 2025. Comparative analysis of reconstitution and solubility characteristics of next-generation injectable poly-l-lactic acid (PLLA)-LASYNPRO\u2122 and first-generation PLLA fillers. Polymers, Available at: https:\/\/www.mdpi.com\/2073-4360\/17\/13\/1778<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

If you\u2019ve been exploring the world of advanced skin rejuvenation, you\u2019ve probably come across Jul\u00e4ine one of the latest collagen-stimulating injectables designed to improve firmness, elasticity, and hydration from within. Unlike traditional fillers that simply add volume, Jul\u00e4ine works by activating your skin\u2019s natural regenerative processes, helping it rebuild collagen and elastin over time. The… Read more… What Are the Side Effects of Jul\u00e4ine Collagen Treatment?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":3142,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-3127","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","entry"],"yoast_head":"\nWhat Are the Side Effects of Jul\u00e4ine Collagen Treatment?<\/title>\n<meta name=\"description\" content=\"Learn about Jul\u00e4ine collagen treatment side effects, recovery expectations, and how to ensure the safest, most effective skin-rejuvenation results.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lmaclinic.com\/lma\/blog\/what-are-the-side-effects-of-julaine-collagen-treatment\" \/>\n<meta property=\"og:locale\" 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