STYLAGE A Breakthrough In Dermal Fillers

STYLAGE A Breakthrough In Dermal Fillers

Dr Ayham Al-Ayoubi: If cosmetic doctors are looking for safety, reliability and efficacy from their aesthetic treatments, they will naturally choose hyaluronic acid (HA), a gold-standard product in aesthetic medicine.

Dr Ayham Al-Ayoubi

It is now almost impossible to imagine basic skincare without it.

But, with so many products on the market, it can be difficult to distinguish one HA from the other.

The new generation of cosmetic doctors are both more informed and demanding than ever; they want safe, long-lasting, natural results with less downtime.

Dr Ayham Al-Ayoubi: STYLAGE uses a patented interpenetrated cross-linked network (IPN-Like Technology) manufacturing process. The addition of mannitol to act against free radicals provides optimal resistance to degradation.

As a result, this innovative formula creates a safe, long-lasting product for all types of wrinkles, and all skin types. The Gels have optimised elasticity for easy modelling and reshaping, even for delicate areas like the nose, temples and hands.

At the same time, they have high viscoelasticity for Good filling capacity and natural aesthetic results.

Dr Ayham Al-Ayoubi: STYLAGE has optimised elasticity for easy modelling and reshaping, even for delicate areas like the nose, temples and hands.

 

WHAT IS HYALURONIC ACID?

Hyaluronic acid (HA) is a natural absorbable glycosaminoglycan, the most abundant essential constituent of the human body, (umbilical cord, eye, synovial fluid, dermis, etc.).

It is naturally present in the dermis and is an essential constituent of the structure of the skin giving it hydration, suppleness and tone. It could be compared to a sponge capable of binding to water and retaining it in the deep layers.

Dr Ayham Al-Ayoubi: The role of hyaluronic acid is therefore essential to maintain the 70% water in young skin!

In other parts of the body however its function is to provide viscosity for the fluids necessary for shock-absorption (joint fluids) and for filling cavities (vitreous humour of the eye).

It is a ubiquitous molecule (identical in all species) which is perfectly tolerated by the organism.

Dr Ayham Al-Ayoubi: Over time and depending on each individual, its concentration and quality reduces both in the dermis and in all the other parts of the body where it is found.

Hyaluronicacid can be of animal origin (extracted from cocks’ combs) or be the result of bio fermentation (bacterial fermentation).

HYALURONIC ACID EFFICACY AND APPLICATIONS

Hyaluronic acid has been used for more than 20 years in many products throughout the world.

Because of its unique rheological properties, biocompatibility, biodegradability, HA has been extensively investigated in drug-delivery applications.

 

IN AESTHETIC MEDICINE

Hyaluronic acid is considered to be a new anti-ageing miracle molecule for skin rejuvenation and soft tissue augmentation (e.g. wrinkle correction, restoring of facial volume and contours).

 

IN COSMETOLOGY

Hyaluronic acid is used as an ingredient in beauty and skin care products because of its moisturizing and anti-ageing properties.

 

IN OPHTHALMOLOGY

Hyaluronic acid, a natural component of the vitreous humor of the eye, has found many successful applications in ophthalmologic surgery (i.e. corneal transplant surgery, cataract surgery, glaucoma, protection of the corneal endothelium etc.).

Furthermore, HA solutions also serve as a viscosity-enhancing component of eye drops and as an adjuvant to eye tissue repair.

IN ORTHOPAEDICS

Hyaluronic acid plays a vital role in the development of cartilage and the maintenance of the sinovial fluid surrounding the joints. Because of its viscoelastic nature and ability to form highly hydrated matrices, HA acts in the joint as a lubricant and shock absorber.

Intra-articular injections of HA are used in joints (e.g. knee, hip, finger, etc.) in order to increase the viscosity of the synovial fluid and provide more cushioning support for joints to move freely without pain.

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Filling and Smoothing Wrinkles 

Dr Ayham Al-Ayoubi: As we get older the skin loses its natural elasticity and we may notice first wrinkles on its surface. With time wrinkles get deeper and turn into un-aesthetic lines. As a result, the face starts to look tired, saggy and less radiant.

The STYLAGEClassic line has been specifically designed to treat all types of wrinkles. Each product is specially formulated and chosen to suit the individual needs according to age, skin type, skin condition and wrinkle depth (size S, M or L).

 

STYLAGE S is most suited for patients with:

• Superficial and average wrinkles;

• Periorbital wrinkles ("crow’s feet");

• Glabellar frown lines (between the eyebrows);

• Fine cheek wrinkles;

• Perioral wrinkles (around the mouth);

• Oral commissures (marionette lines);

• Dark circles (eye hollows) in the tear trough area under the eye.

STYLAGE M is a cross-linked hyaluronic acid based gel formulated with the addition of an antioxidant agent, Mannitol, designed for the treatment of moderate to severe facial lines and medium to deep wrinkles.

 

STYLAGE M is most effective for treating patients with:

• Moderate to severe nasolabel folds;

• Smoothing of wrinkled areas and sagging folds (cheeks, facial oval, chin);

• Oral commissures (marionette lines);

• Cheek wrinkles;

• Hollow temple area;

• Nose: nasal hump reduction, nasal tip lift;

• Earlobe reshaping.

 

STYLAGE L has specifically designed formula to treat patients with:

• Deep to very deep wrinkles;

• Severe nasogenian folds;

• Oral commissures (marionette lines)

STYLAGE L is also very effective treatment for hand rejuvenation, to treat volume loss on the back of the hands.

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Facial Volume Restoration

A youthful face is one that is full and smoothly contoured. As we age, our face naturally loses volume, which can happen as early as our mid-20s or 30s, and especially in those who diet or excessively exercise.

Dr Ayham Al-Ayoubi: As we get older, the face loses its natural volume and its contour is less defined. Loss of volume is one of the most evident forms of facial ageing caused by reduced skin elasticity, diet, stress, smoking and other contributing factors.

The face starts to lose its natural volume and its contours become less defined. Facial features become sharper and the oval of our face loses its shape.

Even if lines or wrinkles are not apparent, the loss of underlying soft tissue can cause drooping or sagging skin, depressed or hollowed cheeks, which eventually give the face a wan, tired appearance.

Therefore, restoring facial volume is an effective and immediate way in which to improve facial proportions and create a natural, youthful look.

Dr Ayham Al-Ayoubi: To give the face attractive volume, Laboratories VIVACY has developed STYLAGE XL,STYLAGE XXL and STYLAGE XL Lidocaine.

STYLAGE XL and STYLAGE XXL will help achieve instant natural results that will last up to 12 months or even more, depending on your skin type, age, lifestyle, the area treated and the injection technique used for the procedure.

STYLAGE XL and STYLAGE XXL are used for the treatment of facial volume defects, restoration and creation of facial contours, cheekbone area augmentation, and treatment of a slight ptosis.

STYLAGE XXL is not only wrinkle filler, but also a volumiser. It is a monophasic cross-linked HA with added mannitol, specifically designed to restore that fullness of youth and provide underlying facial structure in the three most important areas of the face: the cheekbones, facial oval and chin.

Dr Ayham Al-Ayoubi: A clinical study confirmed that the effectiveness of the HA is not compromised by the addition of Lidocaine, and that the performance and filling capacity of gels with STYLAGE Lidocaine are the same as those without.

The study concluded that the product does not bring about any increased risk of blood extravasation and affects neither the quality nor durability of the results.

Although the few seconds it takes to initially insert the product may be uncomfortable, the rest of the injection is far more tolerable.

The correction can therefore be refined under much better conditions. This increased comfort throughout the injection process confirms the notion that the addition of lidocaine is a key step forward in putting the patient at ease.

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What makes STYLAGE it stands out from the crowd?

All HA fillers are cross-linked with a chemical to resist natural degradation and prolong duration. However, STYLAGE uses a patented Laboratories interpenetrated cross-linked network (IPN-Like Technology) manufacturing process, which requires less chemical interference.

STYLAGE is the first product which contains cross-linked HA, antioxidant (Mannitol) and Lidocaine for comfort and safety—for both for patients and cosmetic doctors.

The addition of mannitol to act against free radicals provides optimal resistance to degradation.

Dr Ayham Al-Ayoubi: Mannitol is a naturally occurring antioxidant found in the plant kingdom, and has been used in hospitals for rehydration and life support for many years.

As a result, this innovative formula creates a safe, long-lasting product for all types of wrinkles, and all skin types. STYLAGE has optimised elasticity for easy modelling and reshaping, even for delicate areas like the nose, temples and hands.

At the same time, it has high viscoelasticity for good filling capacity and natural aesthetic results thanks to its smoothing effect.

STYLAGE boasts 12–24 months duration with minimal swelling, including the mid-range medium viscosity products.

STYLAGE can be used to fill and smooth wrinkles, natural lip correction, volume restoration and hydration, chin remodelling, tear trough correction, neck, décolleté and hand rejuvenation.

Innovative anti-ageing solution Facial proportions play a significant role in how beauty is perceived.

STYLAGE is the first innovative monophasic Gels consisting of cross-linked hyaluronic acid (patented IPN-Like technology) and a natural antioxidant to reduce the visual effects of ageing.

Dr Ayham Al-Ayoubi: STYLAGE can be used for filling and smoothing wrinkles, natural lip correction, volume restoration, hydration, chin remodelling, tear trough correction, neck, décolleté and hand rejuvenation. It is also possible to combine products for targeted treatment.

STYLAGE uses a patented interpenetrated cross-linked network (IPN-Like Technology) manufacturing process.

The addition of mannitol to act against free radicals provides optimal resistance to degradation. As a result, this innovative formula creates a safe, long-lasting product for all types of wrinkles, and all skin types.

The Gels have optimised elasticity for easy modelling and reshaping, even for delicate areas like the nose, temples and hands. At the same time, they have high viscoelasticity for Good filling capacity and natural aesthetic results.

STYLAGE has developed an extensive range of Aesthetic and Anti-Aging products for filling lines and wrinkles and for facial volume restoration.

 

IPN-LIKE, A UNIQUE AND PATENTED TECHNOLOGY

Dr Ayham Al-Ayoubi: All hyaluronic acid fillers are cross-linked in order to resist natural degradation and make it last in the skin.

The first innovation involved non-animal biphasic HA gels. The second generation had monophasic gels.

The third generation is now with STYLAGE – a non-animal monophasic hyaluronic acid gels multi-cross-linked with an antioxidant mannitol according to the unique IPN-Like Technology or InterPenetrated Cross-linked Networks.

Thanks to the advanced engineering of Laboratoires VIVACY, IPN-Like technology results in a safe, long-lasting product for all types of wrinkles and skin types. It has optimised elasticity for easy modelling and reshaping, even for delicate areas like the nose, temples and hands.

At the same time it has a high viscoelasticity for good filling capacity and natural aesthetic results thanks to its smoothing effect.

Compared to the classic cross-linking technique, IPN-Like technology, involves combining, inserting one into another, two monophasic hyaluronic acid networks previously purified and cross-linked which are mechanically independent, so that gel is easy to inject and the increased density of its cross-linking nodes requires less BDDE (cross-linking agent) and makes it longer-lasting.

The duration of the treatment is very individual and depends on many factors, such as the patient’s skin type and structure, age, lifestyle, the area treated and the injection technique used by practitioner.

 

INTERPENETRATION OF CROSS-LINKLED NETWORKS:

Optimises the density of the chemical bonds while minimising the use of reticulating agent (BDDE) within the monophasic gel, generating increased remanence.

Preserves the partial independence of the inter-penetrated networks guaranteeing easy regular injection for a more accurate procedure.

Guarantees the consistency of the product and its maintenance at the injection site due to weak bonds (hydrogen, electrostatic, etc.).

Allows an ideal insertion of the gel into the appropriate skin layer.

 

CROSS-LINKING

Dr Ayham Al-Ayoubi: Cross-linking is a process which binds the molecules together by strong covalent chemical bonds, very greatly slowing product breakdown (without cross-linking, the metabolism of the NaHa after intradermal injection takes only several days to several weeks).

So the greater the cross-linking of the product, the more compact it is and the longer it lasts. However, it becomes more difficult to inject.

Cross-linking for the STYLAGE range is performed by a well-known agent (BDDE, or ButaneDiol Diglycidyl Ether, used in the medical field for more than 20 years) in conditions generating ether bonds that are particularly stable in the face of breakdown.

 

 

ANTIOXIDANTS MANNITOL: PROTECTIVE ACTION

During an intradermal injection, the invasive movement of the needle through the skin’s layers provokes an inflammatory response.

Free radicals are then produced that damage cells which puts stress on the skin. During injections, hyaluronic acid will be the first molecules to be attacked by free radicals.

Consequently, the filler injected depletes quickly and results cannot be maintained for prolonged period of time.

Vivacy I.P.N technology mannitol badge the addition of mannitol, an antioxidant naturally found in fruits, certain vegetables and plants, within STYLAGE slows the effects of post-injection radical breakdown.

This means that there is an immediate and maintained result because the product is not broken down in the hours following the injection. This reduction in intradermal skin trauma means that less of the hyaluronic filler is lost during treatment.

A clinical follow-up over one year after the first STYLAGE injection found that the smoothing effect and effectiveness of the treatment observed by both patients and doctors was maintained and very successful.

The quality of skin was dramatically improved. As a thermal stabilizer, mannitol also helps maintain the stability and physico-chemical properties of the STYLAGE gel in the syringe during its storage at room.

 

SORBITOL: MOISTURIZING ACTION

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Dr Ayham Al-Ayoubi : Sorbitol, like mannitol, is an antioxidant agent that acts as a free radical scavenger. Moreover, it has been safely used in pharmaceuticals, cosmetics and beauty products for a long time due to its powerful moisturizing properties.

Complementary to the STYLAGE range with mannitol, sorbitol has been incorporated into STYLAGE HydroMax, a dermal filler specifically developed to improve skin hydration and elasticity.

As a very hygroscopic antioxidant, it helps skin retain water to conserve moisture and thereby keeps it looking healthy and youthful.

STYLAGE HydroMax has been successfully used to treat different areas such as the face, neck, décolleté and hands.

Its innovative formula offers preventive and curative skin care for both young and mature skin with excellent long-term results.

STYLAGE is the first innovative monophasic Gels consisting of cross-linked hyaluronic acid (patented IPN-Like technology) and a natural antioxidant to reduce the visual effects of ageing.

It can be used for filling and smoothing wrinkles, natural lip correction, volume restoration, hydratation, chin remodeling, tear trough correction, neck, décolleté and hand rejuvenation. It is also possible to combine products for targeted treatment.

Behind this breakthrough

The STYLAGE range comes from Laboratories VIVACY, a French manufacturer specialising in the design, manufacturing and distribution of injectable medical devices for use anti-ageing medicine, particularly medical aesthetics and visco supplementation.

Driven by its growing success, VIVACY has made a big investment in a new high-tech manufacturing facility, located in the beautiful and dynamic Haute-Savoie region in France.

Launched in 2008 by Laboratories VIVACY in France, STYLAGE- HA gels fulfil these criteria due to their innovative formulations, which ally quality, safety and efficiency.

Dr Ayham Al-Ayoubi: STYLAGE is not just another HA. It is now one of the leading brands of dermal fillers that have achieved success without consumer marketing, but through clinical experience and peer group recommendation.

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