If you’ve been exploring non-surgical ways to refresh and rejuvenate your skin, you’ve probably come across both Sculptra and Profhilo. These treatments are hugely popular in the aesthetics world, and for good reason they can give noticeable improvements without surgery.
The tricky part is that they work in very different ways. That often leaves people asking, “Which one is actually better for me?” It’s a fair question, and the answer depends on your skin goals and what kind of results you’re hoping to see.
I’ve put together this guide to help you understand the differences. I’ll explain how each treatment works, what results you can realistically expect, and which concerns each one is best suited for.
By the end, you’ll have a much clearer idea of which treatment might be right for you and what improvements you can realistically look forward to.
It’s also worth knowing that choosing the right treatment isn’t just about the latest trends or what your friends are trying. Your skin is unique, and what works beautifully for someone else might not give you the results you want.
Plus, understanding the process and expected outcomes can make a huge difference in how confident and satisfied you feel with your results. Once you know what to expect, you’ll be able to make a more informed choice that’s tailored specifically to your needs.
What Is Sculptra?
Sculptra is a little different from your typical dermal filler. Instead of just adding volume under your skin, it’s often described as a collagen stimulator. It uses an injectable substance called poly-L-lactic acid (PLLA) to gently encourage your body to produce more of its own collagen over time.
Collagen is the protein that gives your skin its firmness and elasticity. From your mid-20s onwards, collagen levels naturally start to drop. This decline is one of the main reasons why wrinkles, hollows, and sagging appear as you get older.
The idea behind Sculptra is to work with your body, not against it. By stimulating your own collagen production, it helps your skin gradually regain volume and resilience, rather than instantly filling lines with a foreign substance.
Because it works slowly, you won’t see dramatic results overnight. The improvements appear gradually over several weeks to months, which makes them look very natural. People often notice a fresher, more youthful appearance without anyone being able to pinpoint exactly what has changed.
Sculptra is especially helpful if you’re looking to restore structure in areas where your skin has thinned or hollowed over time, like your cheeks, temples, or jawline. It can also improve skin texture and firmness overall, giving you a subtle lift without the need for surgery.
Another benefit is that the results tend to last longer than many traditional fillers. Since it’s your own collagen doing the work, the effects can continue to improve for up to two years after treatment, depending on your skin and lifestyle.
What Is Profhilo?
Profhilo is a little different from both fillers and collagen stimulators like Sculptra. Think of it as an injectable moisturiser rather than something that adds volume. Its main ingredient is one of the highest concentrations of hyaluronic acid (HA) available in a single treatment.
Hyaluronic acid is a substance your skin naturally produces. It acts like a sponge, attracting and holding water to keep your skin hydrated, plump, and radiant. Unfortunately, just like collagen, HA levels start to decline as we age, which is why your skin can start to look dull, dry, or saggy over time.
When you receive Profhilo injections just under the surface of your skin, it gives your skin an intense hydration boost. This doesn’t just make your skin feel softer it improves overall texture, smoothness, and brightness, giving a refreshed and youthful appearance.
Another benefit is that while Profhilo’s primary role is hydration, it also encourages some collagen and elastin production, helping your skin become firmer and more elastic over time. Many people describe the results as a “lit-from-within” glow rather than a dramatic change in shape or volume.
Profhilo is particularly ideal if your skin feels dehydrated, tired, or slightly lax, and you’re looking for a subtle lift without adding noticeable volume. It’s less about changing the contours of your face and more about improving the quality and health of your skin.
Key Differences Between Sculptra and Profhilo
To really figure out which treatment might be best for you, it helps to break down the main differences between Sculptra and Profhilo. While both aim to rejuvenate your skin, they do it in very different ways and suit different goals. Understanding these distinctions can make it much easier for you to choose the right approach for your needs.
1. How They Work
Sculptra works by stimulating collagen production deep within your skin using poly-L-lactic acid (PLLA). It’s more about rebuilding the structure of your skin from the inside out. Profhilo, on the other hand, delivers very high levels of hyaluronic acid. This primarily hydrates your skin and smooths the surface, giving a refreshed and radiant appearance rather than adding volume. Essentially, Sculptra reshapes, while Profhilo revitalises.
2. Speed of Results
With Sculptra, you’ll need a bit of patience. Results develop gradually over 6–12 weeks as your skin slowly produces more collagen. Profhilo, however, gives quicker results. Many people notice a visible glow and improved hydration within just a couple of weeks. This makes Profhilo a great choice if you want a noticeable pick-me-up before a special event.
3. Longevity
Sculptra is known for its long-lasting effects. Once you complete your course of treatment, the results can last around 18–24 months, sometimes even longer depending on your skin and lifestyle. Profhilo typically lasts about 6 months, though top-up sessions can extend its benefits. So, if you’re looking for something that keeps working for years, Sculptra might be the better investment.
4. Target Concerns
If your main concerns are volume loss, sagging, hollow cheeks, or deeper wrinkles, Sculptra is usually the better option. Profhilo is ideal if your skin feels dull, dehydrated, or crepey, or if you want to smooth out fine lines while boosting overall skin quality. Choosing the right treatment really comes down to understanding your own skin priorities and goals.
5. Treatment Areas
Sculptra is commonly used on areas like the cheeks, jawline, temples, and even certain body areas where volume has diminished. Profhilo is more versatile for skin quality and hydration and is often applied to the face, neck, décolletage, and hands. Knowing which areas you want to target can help guide your decision between the two.
Who Should Consider Sculptra?
If your main concern is noticeable facial ageing like hollow cheeks, deep folds, or sagging Sculptra is usually the more effective option. Because it helps your skin rebuild its own structure, it addresses the root cause of volume loss rather than just masking it. This makes it ideal if you’re looking for a natural way to restore youthful contours.
It’s also a good choice if you’re patient and prefer results that develop gradually. You won’t walk out of your first session with an instant transformation, but after a few months, the improvements can be truly remarkable. Over time, you’ll notice smoother, firmer skin that looks refreshed without appearing artificial.
Many people choose Sculptra because they want to avoid the “done” look that sometimes comes with traditional fillers. The subtle, progressive changes mean people around you are less likely to notice you’ve had a treatment they’ll just think you look well-rested and rejuvenated.
Sculptra is particularly suited to anyone who wants long-lasting results and is willing to commit to a treatment plan that gradually restores their skin’s natural volume. If you want to work with your body rather than against it, Sculptra might be the perfect fit.
Who Should Consider Profhilo?
Profhilo is perfect if your main complaint is skin quality rather than volume. If you’re noticing that your skin looks dull, thin, or lacks hydration, Profhilo can make a huge difference.
It’s particularly popular among those in their 30s and 40s who want to maintain a youthful glow and prevent deeper ageing signs from setting in. The treatment is also very versatile, since it can be used on the neck, chest, and hands areas that often reveal age even before the face does.
Another benefit is the speed of results. If you have an event coming up and want to look brighter and fresher, Profhilo can deliver visible improvements quickly.
Treatment Experience: What to Expect
Both Sculptra and Profhilo are injectable treatments, but the experience with each is slightly different. Knowing what to expect can help you feel more comfortable and confident going into your sessions.
Sculptra: You will typically need a few sessions often 2–3 spaced several weeks apart, depending on your practitioner’s plan and your skin’s response. The injections are placed a little deeper into the skin, targeting areas where collagen stimulation is most beneficial. Mild swelling, bruising, or tenderness can occur, but these usually settle within a few days and are generally manageable.
Profhilo: This treatment usually involves 2 sessions, spaced about a month apart, though your practitioner may adjust this based on your skin needs. The injections are placed just under the surface at specific points to deliver intense hydration. Small bumps may appear immediately after treatment, but they typically disappear within 24–48 hours. Most people find the process very comfortable, especially when numbing cream is used.
Both treatments allow you to return to normal daily activities immediately. There’s no downtime, so you can carry on with work, social plans, or exercise without interruption. Many people appreciate how convenient and low-maintenance these treatments are, especially compared with more invasive procedures.
Results: Realistic Expectations
One of the most important parts of choosing a treatment is setting realistic expectations. Understanding what each option can and cannot do will help you feel more confident and satisfied with your results.
Sculptra: With Sculptra, you’ll notice gradual improvements in fullness, firmness, and overall facial structure. It won’t freeze your expressions or give you instant volume like traditional fillers, but over time, it can help you look younger in a subtle and natural way. Many people love that the changes are progressive, so they feel refreshed without anyone being able to tell exactly what has been done.
Profhilo: Profhilo works differently. You’ll see smoother, plumper, and more radiant skin relatively quickly. It won’t lift sagging or restore lost cheek volume, but it can take years off your appearance by improving glow, texture, and overall hydration. People often describe the effect as a “lit-from-within” radiance that makes skin look healthier and more youthful.
In both cases, combining treatments with a good skincare routine, sun protection, and healthy lifestyle choices will help you maintain and even enhance your results. Think of these treatments as a boost rather than a replacement for consistent self-care when you take care of your skin, the results last longer and look even better.
Cost Considerations
Costs vary depending on location, clinic, and practitioner experience. Generally:
Sculptra: More expensive due to multiple sessions and longer-lasting results.
Profhilo: More affordable upfront but requires more frequent maintenance.
It’s worth weighing not just the initial price but also the long-term value. For some people, investing in Sculptra makes sense because of its longevity, while others prefer the lower upfront cost of Profhilo.
Safety and Side Effects
Both treatments are considered safe when carried out by qualified professionals. Common temporary side effects include redness, swelling, bruising, or tenderness at the injection site.
Serious side effects are rare but can occur, particularly if the treatment is performed by someone inexperienced. This is why choosing a reputable clinic is absolutely essential.
When considering Sculptra in the UK, always ensure the practitioner is highly trained and experienced with collagen stimulators. The technique is crucial to achieving natural-looking results and avoiding complications.
Can You Combine Sculptra and Profhilo?
Interestingly, these treatments don’t have to be an either/or choice. Many practitioners use them together to maximise results.
For example, Sculptra can restore volume and firmness over time, while Profhilo can enhance hydration and glow. When combined, they address multiple aspects of skin ageing at once.
If you’re open to a tailored approach, speak to your practitioner about whether a combination plan could benefit you.
FAQs:
1. Who makes a good candidate for Sculptra in the UK?
If you’ve started noticing sagging skin, hollow cheeks, or a loss of facial definition, Sculptra might be a great fit for you. It’s particularly suited to people in their 30s, 40s, or older who want a gradual, natural-looking improvement rather than an instant, dramatic change. You should also be in good overall health and free from certain medical conditions that could affect healing. A consultation with a trained practitioner will help confirm if your skin type, age, and goals make you an ideal candidate.
2. Is Profhilo right for you if your main concern is hydration?
Yes, Profhilo is perfect if your skin feels dull, dry, or slightly lax. It works like an “injectable moisturiser,” delivering high concentrations of hyaluronic acid to plump and hydrate your skin from within. If your main priority is improving texture, radiance, and elasticity rather than restoring lost volume, Profhilo can provide a noticeable “lit-from-within” glow in just a few weeks. It’s also excellent if you want a subtle, refreshed look without changing your facial contours.
3. How long will your results last with each treatment?
With Sculptra, results can last 18–24 months or longer because it stimulates your body to produce new collagen over time. The improvements are gradual and continue to develop after your last session. Profhilo offers shorter-term results, typically around 6 months, though you can maintain your refreshed skin by having top-up sessions. When deciding, consider whether you want a long-lasting structural improvement (Sculptra) or a shorter-term hydration boost (Profhilo).
4. Can you combine Sculptra and Profhilo for better results?
Absolutely! You don’t have to choose one over the other. Many practitioners recommend a combined approach if your skin has both volume loss and dehydration. For example, Sculptra rebuilds the structure and firmness of your face, while Profhilo hydrates and improves texture. Together, they can create a more youthful, healthy, and natural-looking result. Your practitioner will design a treatment plan to ensure the timing and placement of injections complement each other safely.
5. How quickly will you see results after treatment?
Profhilo works relatively quickly, with many people noticing smoother, plumper, and more radiant skin within 1–2 weeks. Sculptra takes longer because it works gradually by stimulating collagen production, with visible improvements appearing over 6–12 weeks. If you have an upcoming event and want an immediate glow, Profhilo might be your go-to. But if you’re willing to wait for a subtle, long-lasting transformation, Sculptra is ideal.
6. What’s the treatment experience like?
Both treatments involve injections, but the process differs slightly. With Sculptra, injections are placed a little deeper into the skin to stimulate collagen in targeted areas like cheeks, temples, or jawline. You might feel mild tenderness, swelling, or bruising, which usually settles within a few days. Profhilo injections are more superficial and focus on hydration points, with tiny bumps appearing immediately after treatment that typically disappear within 24–48 hours. Both treatments are low-maintenance, and you can return to your daily routine immediately.
7. Are there any side effects you should know about?
Both Sculptra and Profhilo are generally considered safe when administered by a qualified practitioner. Temporary side effects can include redness, swelling, tenderness, or mild bruising. Serious side effects are rare but can occur if the procedure isn’t performed correctly, which is why choosing an experienced practitioner is crucial. If you follow pre- and post-treatment instructions carefully, you’ll minimise risks and ensure natural, long-lasting results.
8. Which treatment gives the most natural look?
Both treatments are designed for natural results, but they achieve this in different ways. Sculptra gradually restores lost volume and supports your skin’s natural structure over time, avoiding the “overfilled” appearance common with traditional fillers. Profhilo improves hydration and skin quality, giving you a healthy, radiant glow without altering your facial shape. If you want people to notice that your skin looks fresher without guessing you’ve had treatment, either option will work beautifully.
9. How many sessions will you need?
Sculptra usually requires 2–3 sessions, spaced a few weeks apart, to achieve optimal collagen stimulation and long-lasting results. Profhilo typically involves 2 sessions, spaced one month apart. Depending on your skin goals and how quickly your skin responds, your practitioner may recommend occasional maintenance sessions to keep your results looking fresh.
10. How do you choose the right treatment for your goals?
Choosing the right treatment depends on your primary concerns. If you’re worried about sagging, hollow cheeks, or deep folds, Sculptra addresses structural ageing by rebuilding your skin’s collagen. If your skin is dehydrated, dull, or lacking elasticity, Profhilo improves overall skin quality with a soft, radiant finish. Many people benefit from a combined approach, but a personalised consultation with a trained practitioner will help you decide which treatment or combination best meets your unique skin goals.
Final Thoughts: Choosing Between Sculptra and Profhilo
Sculptra and Profhilo both offer remarkable, non-surgical ways to revitalise your skin. Whether you want to restore lost volume with Sculptra or deeply hydrate and smooth your complexion with Profhilo, each treatment delivers natural-looking results and enhances your skin’s overall quality with minimal downtime.
At the London Medical & Aesthetic Clinic, Mr Ayham Al-Ayoubi and our expert team provide tailored treatment plans designed to match your unique skin goals. If you are considering Sculptra in the UK, Profhilo, or a personalised combination of both, Dr Al-Ayoubi’s advanced techniques ensure safe, precise, and beautifully refreshed results that last.
References:
1. Haddad, A. et al., 2025. Injectable Poly-l-Lactic Acid for Body Aesthetic Treatments: An International Consensus on Evidence Assessment and Practical Recommendations. Aesthetic Plastic Surgery (Springer). https://link.springer.com/article/10.1007/s00266-024-04499-9
2. Avelar, L.E. et al., 2025. Comprehensive Systematic Review of Poly-L-Lactic Acid in Facial Clinical Application. Aesthetic Plastic Surgery (Springer). https://link.springer.com/article/10.1007/s00266-025-05030-4
3. Christen, M.O., 2022. A Review Focused on Poly-L-Lactic Acid (PLLA). Clinical, Cosmetic and Investigational Dermatology (Taylor & Francis). https://www.tandfonline.com/doi/full/10.2147/CCID.S359813
4. Stellavato, A. et al., 2016. Hyaluronan Hybrid Cooperative Complexes as a Novel Approach for Skin Bioremodeling: In Vitro Evidence. PLoS ONE (Public Library of Science). https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163510
5. Sparavigna, A. et al., 2024. Efficacy and tolerability of Profhilo® Structura intended to restore lateral cheek fat compartment: An observational pilot study. Journal of Cosmetic Dermatology (Wiley). https://pmc.ncbi.nlm.nih.gov/articles/PMC10801275
